KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation

KLF2 (Kruppel-like factor 2) is a member of the zinc finger transcription factor family, which critically regulates embryonic lung development, function of endothelial cells and maintenance of quiescence in T-cells and monocytes. It is expressed in naïve T-cells and monocytes, however its level of expression decreases during activation and differentiation. KLF2 also plays critical regulatory ro...

متن کامل

NF-κB-Mediated Regulation of Osteoclastogenesis

Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusion of bone marrow-derived myeloid lineage precursors that circulate in the blood. Major advances in understanding of the molecular mechanisms regulating osteoclast formation and functions have been made in the past 20 years since the discovery that their formation requires nuclear factor-κB (NF-κ...

متن کامل

Norcantharidin Facilitates LPS-Mediated Immune Responses by Up-Regulation of AKT/NF-κB Signaling in Macrophages

Norcantharidin (NCTD), a demethylated analog of cantharidin, is a common used clinical drug to inhibit proliferation and metastasis of cancer cells. But the role of NCTD in modulating immune responses remains unknown. Here, we investigated the function and mechanism of NCTD in regulation of TLR4 associated immune response in macrophages. We evaluated the influence of NCTD on host defense agains...

متن کامل

NF-κB and Its Regulation on the Immune System

NF-κB is a transcription factor of eukaryote, five members of whose family in mammals and three in drosophila. Transcription factors of the NF-κB family are activated in response to signals that lead to cell growth, differentiation, apoptosis and other events. NF-κB takes part in expression of numerous cytokines and adhesion molecules which are critical elements involved in the regulation of im...

متن کامل

Regulation of Immune Responses by NF-κB/Rel Transcription Factors

W ithin peripheral lymphoid organs, complex interactions occur between lymphocytes and antigen-presenting cells during an immune response to antigen. Although there is considerable recognition of the fact that activation of innate immune signaling pathways is necessary for productive adaptive immune responses to occur, a great deal is still unknown about how this coordination is achieved at a m...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2017

ISSN: 1422-0067

DOI: 10.3390/ijms18112383